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To date, more than 20 different AFs have been identified with moderate to high toxicity effects on the human body ( Figure 1 The laboratory analysis of AFs identified several metabolized AFs derivatives that rarely found in the human body ( Fusarium species should be taken into account because of their potential to outbreak and influence the future food safety and security ( The upcoming GCC and future AFs contamination risks The GCC is becoming a serious concern, and being the future driver of food safety and security ( Studies disclosed that GCC induces the occurrence of plant fungal pathogens by providing appropriate environmental requirements for their growth and development ( The GCC might support the growth and development of APF in crop production sites ( Different strategies have been applied to address the GCC in advanced and developing countries ( The emerging reports on the GCC demonstrated that GW has begun to occur but the empirical data on how GW might affect crops yield is markedly overlooked ( Therefore, recruiting predictive models to simulate the occurrence of AFs requires an in-depth knowledge of future AFP-GCC interactions ( In this regard, Yu et al