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PRMT5 inhibition was later reported to induce lymphocyte infiltration and MHC II expression in mouse liver HCC tumours, which was demonstrated by an increase in CD45.1, CD4 and CD8 staining in fixed liver tumours and up-regulation of H2-Ab1, Cd74 and MHC II transactivator Ciita at the mRNA level (45)
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Excessive production of ROS can be detrimental to cells, causing damaging key cellular constituents such as proteins, lipids, and DNA
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