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Critically, this E-domain peptide is structurally distinct from the N-terminal 70-amino acid mature IGF-1 sequence shared by all isoforms and is therefore not equivalent to, and does not replicate the pharmacology of, systemic IGF-1 or IGF-1 LR3
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The study was done using fecal samples from people living in a region known for heavy agricultural pesticide use in California, with 61% of the participants having Parkinson’s disease.[ref] Related article: Gut Genes: How Your Genetic Variants Impact Your Gut Microbiome Enough background science
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