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a V H encoded by a nucleic acid comprising a sequence at least about 95% identical to the sequence set forth in SEQ ID NO: 222 or a nucleic acid that the antibody comprises a V H comprising a sequence set forth in SEQ ID NO: 94 and a V L comprising a sequence set forth in SEQ ID NO: 95

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Conversely, VEGFi-induced hypertension may heighten susceptibility to cardiovascular immune-related adverse events, but synergistic hypertension has not been demonstrated clinically