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For example, in vitro experiments indicated that the HDAC inhibitor, Trichostatin A (TSA), has a significant effect on the endogenous expression of RANKL (well known for its significance in bone metabolism) through enhanced acetylation of histones H3 and H4 on the proximal RANKL promoter sequence in bone stromal cells (Fan X, et al., J Cell Biochem., 2004
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