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Considering the close relationship between the neuronal survival environment and mitochondrial function and dynamics and the widespread reports of induction of neuronal death, including pyroptosis, apoptosis, and necroptosis, by imbalanced mitochondrial dynamics or mitochondrial dysfunction, it can be speculated that mitochondria may be a key factor in activating the unique PANoptosis pathway in neurons (Fricker et al., 2018)
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669 Clinical trials have demonstrated that DFO can facilitate the absorption of edema and hematoma after TBI, reduce neuronal degeneration and phospholipid injury
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