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This important research has led to advances in our understanding of the function of the master circadian pacemaker, i.e., the suprachiasmatic nucleus (SCN) (36), which melatonin helps to entrain and to the novel mechanisms of photoreception involved in the regulation of physiological rhythms generally and the pineal melatonin cycle specifically ( Figure 1 ) (37)
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Furthermore, the study did not assess changes in the lipid profile, which are clinically significant in isoprenaline-induced myocardial damage, and this omission may have hindered a better understanding of the cardioprotective effects of the intervention
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