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( 10.1016/j.fertnstert.2019.05.034) [DOI] [PubMed] [Google Scholar] Zhang M, Su YQ, Sugiura K, et al

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Since the 3D structure of the DNA-binding domain of several nuclear receptors have been published earlier than that of the androgen receptor DNA-binding domain, the consequence of several mutations in the androgen receptor DNA-binding domain have been predicted initially on basis of the structure of the glucocorticoid receptor DNA-binding domain (122, 123).This is illustrated in two studies in which 3D-modelling of the mutated DNA binding domain of the androgen receptor predicts the functional activity of mutant receptors (269, 270)