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However, in healthy rats, it may decrease (PS) or increase (LES) the pressure in sphincters[2]
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Their potential detrimental effects on health can be attributed to their capacity to activate transcription factors, such as NF-B, activating protein-1 (AP-1), tumour protein (p53), and Nrf2, as well as cause cell damage through the collapse of the mitochondrial membrane potential, favouring the propagation of reactive species and subsequently the inflammatory process [156]
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