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In addition to de novo synthesis, LA is also absorbed intact from dietary sources, and it transiently accumulates in many tissues
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When macrophages are recruited by adipose tissue due to the overexpression of monocyte chemoattractant protein 1 (MCP1, a chemokine ligand also known as CCL2), hepatic insulin resistance is observed with increased TNFα expression in adipose tissue, but without any change in body weight or adiposity [148]
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