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DSIP: the unresolved delta sleep-inducing peptide DSIP is a nine-amino-acid peptide first characterized from rabbit sleep research in 1977 and originally framed as a candidate endogenous "sleep factor." This page covers what it is, what the small old human studies actually showed, why mechanism and receptor identity remain unresolved, why the pharmacokinetic story is harder than it sounds, and where it sits relative to modern approved insomnia medicines