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Key takeaways: Rifamycin antibiotics, anti-HIV drugs, certain anti-seizure drugs, and some anti-fungal medications can all lower the effectiveness of some birth control methods You should avoid supplements made from St John’s wort and be cautious using activated charcoal if you’re on the pill You don’t need to take supplements while you’re on birth control unless you have a deficiency On this page Have you ever wondered why your doctor asks about medications you’re taking when you’re there for a birth control prescription