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A broader narrative review published in 2024 also concluded that IV glutathione is associated with serious safety concerns — including anaphylaxis and hepatotoxicity , and stressed that there is insufficient evidence to recommend IV use for cosmetic skin lightening

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Of note, a more direct measurement based on tracing experiments with 13 C1,2,3-glucose under refrigerated storage conditions revealed increases in PPP activity in RBCs from leukofiltered units as a function of storage-induced oxidation of rate-limiting enzymes of glycolysis, such as glyceraldehyde 3-phosphate dehydrogenase 16 (GAPDH in Figure 2)