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Natural products in the treatment of pulmonary emphysema: Therapeutic effects and mechanisms of action - ScienceDirect
doi: 10.3389/fendo.2019.00137 407 CaiZHeB
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Recent cryo-EM studies have recently revealed the allosteric regulatory mechanism of GCN5L: succinate, an intermediate in the tricarboxylic acid (TCA) cycle, Induce a 12° helical twist in its C-terminal region, and enhance the substrate binding efficiency of the catalytic pocket through allosteric effects (Runyi, 2022)
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