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Although these two vaccines are not the first approved drugs utilising genetic materials as active ingredients, they are believed to be a milestone in modern medical history that may forever change pharmaceutical approaches
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These distinctions have therapeutic implications: the IBDS strategy targeting mitochondrial iron chelation with ferritin synthesis promotion addresses ferritinophagy-driven ferroptosis, while NRF2 activation or TNF-α neutralization may be more appropriate for macrophage-mediated scenarios
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