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As the newborn's antioxidant mechanisms are immature and the skin has low antioxidant capacity, blue light directly induces the generation of free oxygen radicals, which may cause DNA damage in the mitochondria and nucleus of the cell (41,103)

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At 21 days, IGF-1 supplementation affected fibril diameter positively compared to the FBS groups but overall, the patterns of content and diameter were similar with the highest value for 0.5% FBS+ IGF-1-treated samples