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Functionally, SPP1 + TAMs play a central role in promoting tumor cell epithelial-mesenchymal transition (EMT), angiogenesis, intravasation, metastasis, and immunosuppression through the secretion of factors including SPP1, CCL18, CXCL8, TNF-α, and IL-1β
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Conclusion CFLD arises from a complex interplay of epithelial, immune, microbial, and vascular factors extending beyond the classical secretory defect hypothesis
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