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2 Disability accumulation results from a combination of these processes in the form of incomplete recovery from an acute immune-mediated inflammatory event known as “relapse-associated worsening,” and functional decline resulting from persistent CNS inflammation and neurodegeneration is known as “smoldering-associated worsening,” although this term requires more precise characterization (see Figure 1 for a summary of the clinical manifestations of relapse-associated and smoldering-associated worsening)

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[DOI] [PubMed] [Google Scholar] Pennypacker 1992 Pennypacker LC, Allen RH, Kelly JP, Matthews LM, Grigsby J, Kaye K