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A cutoff value of 10.2 nmol/mg for GSH was identified, and the area under the ROC curve was 0.913, with a sensitivity of 90.2% and a specificity of 81.8%, demonstrating significant predictive capability in differentiating between the resistant group and sensitive group

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115 This binding then elicits a cascade of intracellular signaling events involving the dephosphorylation of p38 mitogen-activated protein kinase and the phosphorylation of Janus kinase 2, signal transducer and activator of transcription 5, serine/threonine protein kinase B, serum and glucocorticoid-regulated kinase 1 and glycogen synthase kinase 3β