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Additionally, loss of function mutations in the tumor suppressor KEAP1 have been shown to power one-carbon metabolism in NSCLCs (DeNicola et al., Oncogenic mutations promoting constitutive KRAS activation, one of the most common occurrences in cancer, correlates with increased expression of folate cycle enzymes (Moran et al., The tumor suppressor p53 is also known to play a key role in one-carbon metabolism regulation
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