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Initially, the primary mechanism of the repair was thought to stem from their trophic and immunomodulatory effects mediated via the paracrine secretion of various cytokines such as IL-10, PGE2, IL-8, and VEGF (Ranganath et al., 2012)
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Furthermore, the platform is biased toward more hydrophobic regions on the target, thereby limiting its use in targets that form interactions using polar groups 209 3.3.3
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