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The blood–CSF barrier in the choroid plexus controls molecular and immune cell entry into the CSF, ensuring CNS homeostasis [66]

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The receptors from Group II are expressed only in a few brain regions: mGlu2 in the cerebellar and cerebral cortex, hippocampus, olfactory bulbs, and it is located in presynaptic, postsynaptic, or glial sites whereas mGlu3 is predominantly expressed in the dentate gyrus, nucleus accumbens, lateral septal nucleus, cerebral cortex, cerebellar cortex, striatum, substantia nigra pars reticulata, amygdaloid nuclei, and it is located only in the preterminal region of neurons away from synaptic sites [176,185]