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Unlike the allosteric activator compound 102 , the GPX4 inhibitor RSL3 binds to the substrate binding site
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In gsa2 seedlings, the 35S promoter-driven expression of the Cys→S substitution mutants of GSSAT resulted in wild-type-like green pigmentation of the leaves, which indicates that the GSAAT2-deficient phenotype can be rescued by all GSAAT1 variants ( Supplementary Figure 3A )
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