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Nanoparticles encapsulating drugs can be delivered to the CNS for treating Alzheimer's disease through various pathways, including intravenous, intranasal, intracerebroventricular, intrathecal, and intraparenchymal routes[44] (Fig
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However, excess ROS production can lead to oxidative stress (OS) (Grimm and Eckert, 2017), which causes damage to lipids, proteins and deoxyribonucleic acid (DNA), leading eventually to inflammation, apoptotic cell death, and tissue damage (Fig
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