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The reduction of AZA metabolism causes excessive accumulation of cytotoxic compounds, TGNs, inducing severe toxicity such as bone marrow toxicity and GI manifestations (Murugesan et al., 2009)
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The rate of recurrence was 28 % after reinitiating ATRA.72 In 240 APL patients from the Intergroup Protocol 0129 (I0129), probable PTC occurred in 1.7 % of patients (ages: 4–24 years old) who received ATRA 45 mg/m2/day during induction or maintenance
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