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Phase 2 failed primary endpoint Attribute Unique advantage SLU-PP-332 Only pan-ERR agonist with demonstrated in-vivo exercise-mimetic activity MOTS-c Endogenous mitochondrial peptide with AMPK-focused signaling AOD-9604 Most human clinical history of the three Half-life and dose figures across the three compounds are mostly from animal data and should not be read as validated human pharmacology

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Conceptually, in the implementation of the cytoprotection concept (huge pleiotropic beneficial effect of the cytoprotective agent [16,17,18,19,20,21]) for BPC 157 therapy effects, seen from the original viewpoint of the gut peptides’ significance and brain relation [1], we reviewed a wide beneficial effect, both peripherally and centrally, as essential for the harmony of the brain–gut and gut–brain axes’ function

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