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Sattar N, Lee MM, Kristensen SL, Branch KR, Del Prato S, Khurmi NS, et al

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Phospholipids in the brain are particularly vulnerable entities for ROS-mediated peroxidation, but proteins and DNA also are targeted by ROS, which becomes particularly problematic during aging, as aged brains have been reported to exhibit high levels of oxidative stress–induced mutations in the mitochondrial DNA (Gross et al., 1969