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Vitamin B12 Injections | Dr. Robert Fortino
Functional Constipation Key pathological changes in the ENS associated with functional constipation predominantly include a reduction in neuronal density within the myenteric plexus, dysfunction of nitrergic neurons, and delayed intestinal motility
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In HD, the mutant HTT protein impairs mitochondrial biogenesis by interfering with PGC-1α, alters fission/fusion dynamics (affecting MFN1/OPA1), disrupts calcium handling, and promotes mitochondrial permeability transition pore (mPTP) opening
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