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Since CBS induces the expression of cystine importer SLC7A11 in HK-2 cells (Figure 3D), we further supplied the cells with 0.1 mg/ml of cystine in the culture medium, which dramatically increased the absorption of bismuth (Figure 5A)

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Although oxidative stress has historically been considered to be involved mainly in neurodegenerative disorders such as Alzheimer disease, Huntington disease, and Parkinson disease, its involvement in neuropsychiatric disorders, including anxiety disorders and depression, is beginning to be recognized