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102 The mechanisms that mediate PRL effects on β‐cells involve increased osteoprotegerin synthesis, leading to the inhibition of receptor activator of NF‐kB ligand pathway, an inhibitor of β‐cell proliferation, increased survivin levels, promotes the expression of the transcription factors Foxm1 and MafB, increased cyclin activity, and higher islet serotonin production through Tph1 synthesis, all promoting β‐cell proliferation