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Transcriptome and proteome analyses by Filippenkov, Stavchansky, and colleagues published in Genes in 2020 and by Sudarkina, Filippenkov, and colleagues in the International Journal of Molecular Sciences in 2021 confirmed Semax's protective signature following cerebral ischemia-reperfusion in rodent models

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The Injection (Subcutaneous) - Dosing: Once weekly - Bioavailability: ~100% (bypasses GI tract) - Weight loss in trials: Up to 22% at 36 weeks - Best for: Patients seeking maximum efficacy, comfortable with self-injection The Pill (Oral) - Dosing: Once daily (taken on an empty stomach, similar to Rybelsus) - Bioavailability: Lower than SC (relies on SNAC absorption technology) - Weight loss in trials: Up to 13.1% at 12 weeks (Phase 1 — short duration) - Best for: Injection-averse patients, early treatment, maintenance, broader access The oral formulation will almost certainly deliver less weight loss than the subcutaneous version at equivalent treatment durations

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