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The Effects of Proton Pump Inhibitors in Acid Hypersecretion-Induced Vitamin B12 Deficiency: A Systematic Review (2022) | Cureus
not a controlled trialPhase II ulcerative colitis studyReported effective and well toleratedDoes not confirm broader clinical usesAnimal dose-response studiesActive ranges around 10 µg–10 ng/kgDoses not validated for human prescribing These numbers show why experts urge caution
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It was suggested that they showed a particular venous expression, distinctive between the pathways that were occluded (inferior caval vein), appeared as bypassing pathway (left ovarian vein), or blinded pathway (right ovarian vein) (Vukojevic et al., 2018)
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