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In summary, as an enzyme cofactor, ASC participates in abiotic stress responses by modifying plant cell composition, coordinating phytohormone biosynthesis, and regulating gene expression via epigenetic pathways (Figure 2)
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It appears that old age per se is not a risk factor for APAP toxicity, however, co-morbidities with impaired liver function, low body weight, polypharmacy, etc
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