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Insulin resistance results in increased estrogen levelsboth by increasing aromatase activity, resulting in the conversion of testosterone into estrogen, and by decreasing sex-hormone-binding globulin, resulting in greater amounts of free circulating estrogen.[2] Insulin resistance also causes increased production of inflammatory mediators, which likely contributes to estrogen-sensitive conditions including fibroids
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The H 2 DCFDA is permeable to the cell membrane and oxidized to fluorescent 2β, 7β-dichlorofluorescein by various ROS including hydrogen peroxide, hydroxyl radicals and peroxynitrite
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