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Consequently, abnormal mechanisms of cystine and glutamate exchange make the Xc-system a potential contributor to many CNSD (Adla et al., 2024)
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The chimeric rh4F12 mAb, containing the original mouse fragment antigen binding (Fab) region fused with human IgG1 crystallizable fragment (Fc), showed increased potency relative to the original mouse antibody, possibly due the presence of human IgG1 Fc, which is thought to enhance complement fixing activity (Singh et al., 2020)
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