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Because of its strong antioxidant effect, vitamin E is important for the immune system and endothelial functioning as well as protection of cells and tissues from free radicals by inhibiting fat oxidation ( Based on a phase 2 trial including 45 HNSCC patients, a combined regimen consisting of isotretinoin, interferon α-2a, and vitamin E prevents secondary cancers and relapse, which is an effective prevention ( Similarly, vitamin E intake has been shown to decrease the likelihood of breast cancer recurrence ( Another study reported that vitamin E supplement users had a decreased risk of death by 18% (hazard ratio (HR) = 0.82, 95% CI: 0.65–1.02) and a lowered risk of recurrence by 22% (HR = 0.78, 95% CI: 0.63–0.95) ( A prospective, double-blinded, randomized, placebo-controlled study showed that short-term supplementation with vitamin E has a protective effect against radiation therapy-induced dry-mouth (Kim ( Likewise, with the suspension of supplements, the experimental group showed a reduced incidence of secondary neoplasms (39/1000 versus 69/1000, HR = 0.57, 95% CI = 0.31 to 1.0), and it was significantly lower when α-tocopherol was the only supplement (HR = 0.41, 95% CI = 0.16 to 1.03) ( When radiation therapy began, 343 out of 540 patients (60% of the total) smoked

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