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Homocysteine: Genetics, High Homocysteine Levels, and Solutions

The repetitive presence of these residues makes them a preferred substrate of the enzyme tissue transglutaminase (tTG), whose main function is to catalyse the covalent and irreversible cross-linking of a glutamine residue in glutamine-donor proteins with a lysine residue in glutamine-acceptor proteins, which results in the formation of DQ-“gluten” peptide complexes [20]

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(143) elucidated the adverse effects of oxidative stress and chronic inflammation on ovarian functionality, suggesting that exogenous estrogen supplementation may mitigate chronic low-grade inflammation and enhance follicular development