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Gut microbiome metabolites in lung cancer: The emerging importance of short-chain fatty acids - ScienceDirect
One study reported that the scaffold protein phosphatidylethanolamine binding protein 1 (PEBP1) binds to 15-lipoxygenase (15LOX) and directs it to PUFAs in the membrane, thereby facilitating ferroptosis [81]
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Dickkopf (DKK)-1 suppresses prostaglandin endoperoxide synthase (PTGS)-2-induced macrophage and neutrophil recruitment to lung metastases by antagonizing cancer cell non-classical WNT/Planar cell polarity (PCP)-RAC1-JNK signaling, whereas it encourages breast-to-bone metastasis by modulating classical WNT signaling of osteoblasts (99)
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