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The lipid bilayer of the phytosomes helps contact-facilitated drug delivery in which there is a lipid–lipid interaction between the carrier and the cell membrane, leading to the diffusion of the bioactive compounds into the cell
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Therefore, both temporal and spatial considerations of IGF-1R modulation will need to be considered in future trials with these drugs in order to clearly define the benefits and potential risks associated with this treatment, and guide development of strategies that allow for safe and effective long-term human use
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