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Research also suggests that GLP-1RAs may be associated with a broader spectrum of cutaneous adverse events, including urticaria, angioedema, and generalized hypersensitivity reactions, as well as rare immune-mediated conditions such as bullous pemphigoid and pemphigus vulgaris [146,147,148,149,150]

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This ability of the glutathione S -conjugate to act as a dispersant of methyl isocyanate, which is widely used in the chemical industry, is worrisome because of the risk to workers of accidental exposure (which was tragically observed in an industrial accident in Bhopal, India, that resulted in a exposure of a large number of people to methyl isocyanate and many deaths (Samarth et al., 2013, Mishra et al., 2015))