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In addition, many AMPK activators, for example, metformin, polyphenols, short-chain fatty acids, oligosaccharides, and some nutrient-sensing GPCR agonists, were also shown to enhance tight junction integrity

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Mark Hyman Risks increase the longer you take them: Increased risk of bowel obstruction (up 450% after 4 years) Increased risk of pancreatitis (up 900% after 4 years) Potential thyroid issues Kidney issues Nausea and vomiting are common Most people don’t need these drugs if they understand how to change hormones naturally Food can be used as a drug Different foods have different properties for different conditions Ketogenic diets have been used for epilepsy for decades Now we know they can help with schizophrenia, autism, Alzheimer’s, bipolar, depression, anxiety Mayo Clinic got $3 million to research ketogenic diets for mental illness Stanford has a department of metabolic psychiatry Harvard has nutritional psychiatry 01:51:29 – Cancer, Diets & Alcohol Cancer rates are going up because our metabolic crisis is going up Many cancers are obesity related (colon, breast, pancreatic, prostate) They’re driven by insulin resistance Cancer has a metabolic capacity to only burn carbs, not fat If you stop carbs and eat fat, you can change the trajectory of cancer This isn’t true for all cancers, probably not for certain lymphomas Dr