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In vivo experiments confirmed that the MPO/HOCl signaling pathway was significantly activated in the plasma and neurons of SOD1 G93A transgenic mice, which upregulated Caspase-3 expression, downregulated GPX4 and NQO1 expression, significantly elevated plasma MDA levels, promoted neuronal apoptosis, ferroptosis, and lipid peroxidation, and reduced motor performance in mice (Peng et al., 2022)
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doi: 10.3390/antiox10071087, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 125.Nopriyati NR, Thaha A, Diba S, Yahya YF, Aryani IA
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