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GSH undergoes thiol-disulfide exchange in a reaction catalyzed by thiol-transferase as follows: Since this reaction is a reversible reaction, the equilibrium is determined by the redox state of the cell, which depends on the concentrations of GSH and GSSG (proportional to the log of [GSH] 2 /[GSSG]) (Lu, 1999a)
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If there is a higher demand for GSH because of oxidative stress, such as during viral infection [102], extreme or endurance exercise [103], and hypoxic conditions [22, 94], it will have an inhibitory effect on inorganic sulfate synthesis
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