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Injection Treatment Details Duration Approximately 5-10 minutes per injection Precision Delivery Direct intramuscular or subcutaneous delivery for optimal absorption Convenient Service Administered at your location by our medical professionals Quick Results Faster absorption than oral supplements with immediate effects Stay well-hydrated before your appointment Eat a light meal 1-2 hours prior Wear clothing that allows easy access to upper arm or thigh Inform us of any medication allergies Gently massage the injection site to promote absorption Apply ice if any minor swelling occurs Avoid strenuous exercise for 1 hour Drink plenty of water post-injection Service Areas Tampa Bay Area Sarasota Bradenton Lakewood Ranch Palmetto Manatee County Additional travel fees may apply outside primary service areas How It Works 1

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Etiology Genetics COL5A1 or COL5A2 mutation in 40-50% less common mutations identified below Associated conditions Connective tissue disorder characterized by hyperelastic/fragile skin joint hypermobility and dislocation generalized ligamentous laxity poor wound healing early onset arthritis additional features Classification Berlin Classification (1988) - revised Types I - XI exist Types II and III - most common and least disabling Villefranche Classification (1998) Presentation Symptoms double-jointedness easily damaged, bruised, & stretchy skin easy scarring & poor wound healing increased joint mobility, joint popping, early arthritis especially shoulders, patellae, ankles chronic musculoskeletal pain (50%) Physical exam a score of 5 or more on 9-point Beighton-Horan scale defines joint hypermobility