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PCR data showed that 200 µM H 2 O 2 treatment upregulated IL-1β, MMP13, Collagen-X, Caspase3, and Caspase9 at mRNA level in chondrocytes, while metformin significantly attenuated these H 2 O 2 exposure induced increases (Fig
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However, this phenomenon was observed in some contexts, but not others, hinting that alternate ISR activation pathways may exist
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