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A case report by Lin et al (85) described a 24-year-old patient with HCU with notable complications, including cerebellar infarctions and hypertension, who underwent a liver transplant, after which their metabolic control normalized without dietary restrictions
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Taking advantage of the reactivity of the newly forged double bond, compound 11 underwent dihydroxylation to afford 14 in 40% yield, with concomitant oxidation at C2 and C3
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