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Indeed, other studies involving different -omics time-series analyses challenge the concept of discrete and sequential phases of adaptive fasting, with evidence of transcriptional responses associated with putative late adaptive stages (eg, lipid catabolism) already evident at early timepoints (257, 258), also in line with evidence in mice that nervous system control of adipocyte lipolysis is triggered at an early fasting stage by depletion of liver glycogen (259)

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