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NSAIDs, including topical ibuprofen, have also been studied, showing reduced pain and improved quality of life in patients with lower leg ulcers [136,137,138,139,140]
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The benzyl alcohol preservative has been linked to severe toxicity in this population, including a potentially fatal condition known as “gasping syndrome.” Newborns have immature metabolic pathways and cannot efficiently metabolize benzyl alcohol, leading to its accumulation and metabolic acidosis with respiratory failure in severe cases
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