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Other action mechanisms of caffeine are also described, such as inhibition of phosphodiesterases (cyclic AMP inactivating enzymes) or mobilization of intracellular calcium ( Figure 1 Note: Adenosine is a potent endogenous neuromodulator, which inhibits the release of several neurotransmitters, such as glutamate, gamma-aminobutyric acid, acetylcholine and monoamines ( As for coffee beans, chlorogenic acids (GCA) are the major phenolics present in silverskin