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AlphaFold2-multimer modeling performed in a previous study 16 , suggested that out of the 6 hATG8s, GABARAPL2 was strongly preferred for the LIR1-LDS binding mode with 72% of the top models resulting in such complex (Figs
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To examine this response in vivo, we employed a mouse model of tuberous sclerosis complex involving xenograft tumors derived from the rat TSC2 -/- tumor cell line ELT3 (Hodges et al., 2002)
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